homeobox B1
Symbol
HOXB1
(may also be known as: None)
Organism
Human
Description
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| lab | Drosophila melanogaster | |
| hoxb1a | Danio rerio | |
| Hoxb1 | Mus musculus | |
| Hoxb1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2403 | homeo box B1 decreases with age | Molecular | dermis | Human | HOXB1 | 15.6% Decrease DNA Methylation | |
| DAA2452 | homeo box B1 decreases with age | Molecular | mesenchymal stem cell | Human | HOXB1 | 49.3% Decrease DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007389 | pattern specification process | biological_process | |
| GO:0009952 | anterior/posterior pattern specification | biological_process | |
| GO:0021570 | rhombomere 4 development | biological_process | |
| GO:0021571 | rhombomere 5 development | biological_process | |
| GO:0021612 | facial nerve structural organization | biological_process | |
| GO:0021754 | facial nucleus development | biological_process | |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0048646 | anatomical structure formation involved in morphogenesis | biological_process | |
| GO:0048704 | embryonic skeletal system morphogenesis | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0019904 | protein domain specific binding | molecular_function | |
| GO:0043565 | sequence-specific DNA binding | molecular_function | |