anaphase promoting complex subunit 4
Symbol
ANAPC4
(may also be known as: None)
Organism
Human
Description
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| APC4 | Drosophila melanogaster | |
| anapc4 | Danio rerio | |
| Anapc4 | Mus musculus | |
| Anapc4 | Rattus norvegicus | |
| cut20 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2100 | anaphase promoting complex subunit 4 decreases with age | Molecular | ovary | Human | ANAPC4 | 35.5% Decrease Gene Expression Level | |
| DAA3818 | Gene expression of ANAPC4 increases with age | Molecular | skin | Human | ANAPC4 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000075 | cell cycle checkpoint | biological_process | |
| GO:0000086 | G2/M transition of mitotic cell cycle | biological_process | |
| GO:0000090 | mitotic anaphase | biological_process | |
| GO:0000278 | mitotic cell cycle | biological_process | |
| GO:0006511 | ubiquitin-dependent protein catabolic process | biological_process | |
| GO:0007067 | mitosis | biological_process | |
| GO:0007094 | mitotic cell cycle spindle assembly checkpoint | biological_process | |
| GO:0016567 | protein ubiquitination | biological_process | |
| GO:0030071 | regulation of mitotic metaphase/anaphase transition | biological_process | |
| GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | biological_process | |
| GO:0051301 | cell division | biological_process | |
| GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | biological_process | |
| GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | biological_process | |
| GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | biological_process | |
| GO:0070979 | protein K11-linked ubiquitination | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005654 | nucleoplasm | cellular_component | |
| GO:0005680 | anaphase-promoting complex | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0004842 | ubiquitin-protein ligase activity | molecular_function | |
| GO:0019903 | protein phosphatase binding | molecular_function | |