anaphase promoting complex subunit 4

Symbol

ANAPC4 (may also be known as: None)

Organism

Human

Description

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
APC4	Drosophila melanogaster
anapc4	Danio rerio
Anapc4	Mus musculus
Anapc4	Rattus norvegicus
cut20	Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2100	anaphase promoting complex subunit 4 decreases with age	Molecular	ovary	Human	ANAPC4	35.5% Decrease Gene Expression Level
DAA3818	Gene expression of ANAPC4 increases with age	Molecular	skin	Human	ANAPC4	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000075	cell cycle checkpoint	biological_process
GO:0000086	G2/M transition of mitotic cell cycle	biological_process
GO:0000090	mitotic anaphase	biological_process
GO:0000278	mitotic cell cycle	biological_process
GO:0006511	ubiquitin-dependent protein catabolic process	biological_process
GO:0007067	mitosis	biological_process
GO:0007094	mitotic cell cycle spindle assembly checkpoint	biological_process
GO:0016567	protein ubiquitination	biological_process
GO:0030071	regulation of mitotic metaphase/anaphase transition	biological_process
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological_process
GO:0051301	cell division	biological_process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological_process
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological_process
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological_process
GO:0070979	protein K11-linked ubiquitination	biological_process
GO:0005634	nucleus	cellular_component
GO:0005654	nucleoplasm	cellular_component
GO:0005680	anaphase-promoting complex	cellular_component
GO:0005829	cytosol	cellular_component
GO:0004842	ubiquitin-protein ligase activity	molecular_function
GO:0019903	protein phosphatase binding	molecular_function
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