guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

Symbol

GNAI2 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far. [provided by RefSeq, Oct 2009]

Orthologs

SymbolSpecies
G-ialpha65A Drosophila melanogaster
gnai2b Danio rerio
Gnai2 Mus musculus
Gnai2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2068 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 increases with age Molecular ovary Human GNAI2 58.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000186 activation of MAPKK activity biological_process
GO:0001973 adenosine receptor signaling pathway biological_process
GO:0006184 GTP catabolic process biological_process
GO:0007049 cell cycle biological_process
GO:0007165 signal transduction biological_process
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0007193 inhibition of adenylate cyclase activity by G-protein signaling pathway biological_process
GO:0007194 negative regulation of adenylate cyclase activity biological_process
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway biological_process
GO:0007214 gamma-aminobutyric acid signaling pathway biological_process
GO:0007243 intracellular protein kinase cascade biological_process
GO:0007268 synaptic transmission biological_process
GO:0007584 response to nutrient biological_process
GO:0007596 blood coagulation biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0030168 platelet activation biological_process
GO:0050805 negative regulation of synaptic transmission biological_process
GO:0051301 cell division biological_process
GO:0051927 negative regulation of calcium ion transport via voltage-gated calcium channel activity biological_process
GO:0005624 membrane fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005813 centrosome cellular_component
GO:0005829 cytosol cellular_component
GO:0005834 heterotrimeric G-protein complex cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005886 plasma membrane cellular_component
GO:0030496 midbody cellular_component
GO:0031234 extrinsic to internal side of plasma membrane cellular_component
GO:0045121 membrane raft cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0001664 G-protein coupled receptor binding molecular_function
GO:0003924 GTPase activity molecular_function
GO:0004435 phosphatidylinositol phospholipase C activity molecular_function
GO:0004871 signal transducer activity molecular_function
GO:0005085 guanyl-nucleotide exchange factor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005525 GTP binding molecular_function
GO:0019001 guanyl nucleotide binding molecular_function
GO:0031683 G-protein beta/gamma-subunit complex binding molecular_function
GO:0046872 metal ion binding molecular_function