guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

Symbol

GNAI2 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far. [provided by RefSeq, Oct 2009]

Orthologs

Symbol	Species
G-ialpha65A	Drosophila melanogaster
gnai2b	Danio rerio
Gnai2	Mus musculus
Gnai2	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2068	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 increases with age	Molecular	ovary	Human	GNAI2	58.0% Increase Gene Expression Level

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GO Terms

GO ID	GO Term	GO Category
GO:0000186	activation of MAPKK activity	biological_process
GO:0001973	adenosine receptor signaling pathway	biological_process
GO:0006184	GTP catabolic process	biological_process
GO:0007049	cell cycle	biological_process
GO:0007165	signal transduction	biological_process
GO:0007186	G-protein coupled receptor signaling pathway	biological_process
GO:0007193	inhibition of adenylate cyclase activity by G-protein signaling pathway	biological_process
GO:0007194	negative regulation of adenylate cyclase activity	biological_process
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	biological_process
GO:0007214	gamma-aminobutyric acid signaling pathway	biological_process
GO:0007243	intracellular protein kinase cascade	biological_process
GO:0007268	synaptic transmission	biological_process
GO:0007584	response to nutrient	biological_process
GO:0007596	blood coagulation	biological_process
GO:0008284	positive regulation of cell proliferation	biological_process
GO:0030168	platelet activation	biological_process
GO:0050805	negative regulation of synaptic transmission	biological_process
GO:0051301	cell division	biological_process
GO:0051927	negative regulation of calcium ion transport via voltage-gated calcium channel activity	biological_process
GO:0005624	membrane fraction	cellular_component
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005813	centrosome	cellular_component
GO:0005829	cytosol	cellular_component
GO:0005834	heterotrimeric G-protein complex	cellular_component
GO:0005856	cytoskeleton	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0030496	midbody	cellular_component
GO:0031234	extrinsic to internal side of plasma membrane	cellular_component
GO:0045121	membrane raft	cellular_component
GO:0000166	nucleotide binding	molecular_function
GO:0001664	G-protein coupled receptor binding	molecular_function
GO:0003924	GTPase activity	molecular_function
GO:0004435	phosphatidylinositol phospholipase C activity	molecular_function
GO:0004871	signal transducer activity	molecular_function
GO:0005085	guanyl-nucleotide exchange factor activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0005525	GTP binding	molecular_function
GO:0019001	guanyl nucleotide binding	molecular_function
GO:0031683	G-protein beta/gamma-subunit complex binding	molecular_function
GO:0046872	metal ion binding	molecular_function
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