acyl-CoA dehydrogenase family, member 8

Symbol

ACAD8 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009]

Orthologs

SymbolSpecies
acdh-9 Caenorhabditis elegans
acad8 Danio rerio
Acad8 Mus musculus
Acad8 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3791 Gene expression of ACAD8 decreases with age Molecular skin Human ACAD8 —

GO Terms

GO IDGO TermGO Category
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006629 lipid metabolic process biological_process
GO:0009083 branched chain family amino acid catabolic process biological_process
GO:0034641 cellular nitrogen compound metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005739 mitochondrion cellular_component
GO:0005759 mitochondrial matrix cellular_component
GO:0003995 acyl-CoA dehydrogenase activity molecular_function
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors molecular_function
GO:0050660 flavin adenine dinucleotide binding molecular_function