acyl-CoA thioesterase 11
Symbol
ACOT11
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| acot11b | Danio rerio | |
| Acot11 | Mus musculus | |
| Acot11 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006631 | fatty acid metabolic process | biological_process | |
| GO:0009266 | response to temperature stimulus | biological_process | |
| GO:0009409 | response to cold | biological_process | |
| GO:0035556 | intracellular signal transduction | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0004091 | carboxylesterase activity | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0047617 | acyl-CoA hydrolase activity | molecular_function | |