arachidonate 5-lipoxygenase

Symbol

ALOX5 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Orthologs

SymbolSpecies
zgc:136911 Danio rerio
Alox5 Mus musculus
Alox5 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2987 Gene expression of ALOX5 increases with age Molecular skin Human ALOX5 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1969 Alox5 arachidonate 5-lipoxygenase (5-LOX) mRNA expression decrease Molecular heart Mouse Alox5 —
DAA1965 Alox5 arachidonate 5-lipoxygenase (5-LOX) mRNA expression increase Molecular heart Mouse Alox5 —
DAA1963 Alox5 arachidonate 5-lipoxygenase (5-LOX) promoter methylation increase Molecular heart Mouse Alox5 —
DAA1964 Alox5 arachidonate 5-lipoxygenase (5-LOX) promoter methylation increase Molecular cerebellum Mouse Alox5 —

GO Terms

GO IDGO TermGO Category
GO:0002526 acute inflammatory response biological_process
GO:0002540 leukotriene production involved in inflammatory response biological_process
GO:0006691 leukotriene metabolic process biological_process
GO:0006692 prostanoid metabolic process biological_process
GO:0007584 response to nutrient biological_process
GO:0019233 sensory perception of pain biological_process
GO:0019369 arachidonic acid metabolic process biological_process
GO:0019370 leukotriene biosynthetic process biological_process
GO:0019372 lipoxygenase pathway biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045907 positive regulation of vasoconstriction biological_process
GO:0055093 response to hyperoxia biological_process
GO:0005625 soluble fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005635 nuclear envelope cellular_component
GO:0005641 nuclear envelope lumen cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0016020 membrane cellular_component
GO:0016363 nuclear matrix cellular_component
GO:0030425 dendrite cellular_component
GO:0031965 nuclear membrane cellular_component
GO:0042383 sarcolemma cellular_component
GO:0004051 arachidonate 5-lipoxygenase activity molecular_function
GO:0005506 iron ion binding molecular_function
GO:0005515 protein binding molecular_function
GO:0016165 lipoxygenase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0046872 metal ion binding molecular_function