zinc finger, MYND-type containing 8
Symbol
ZMYND8
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CG1815 | Drosophila melanogaster | |
| zmynd8 | Danio rerio | |
| Zmynd8 | Mus musculus | |
| Zmynd8 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA3741 | Gene expression of ZMYND8 increases with age | Molecular | skin | Human | ZMYND8 | — | |
| DAA2446 | protein kinase C binding protein 1 isoform a increases with age | Molecular | mesenchymal stem cell | Human | ZMYND8 | 19.9% Increase DNA Methylation | |
| DAA2397 | zinc finger, MYND-type containing 8 increases with age | Molecular | dermis | Human | ZMYND8 | 19.5% Increase DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0001106 | RNA polymerase II transcription corepressor activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |
| GO:0070491 | repressing transcription factor binding | molecular_function | |