sirtuin 1

Symbol

SIRT1

Organism

Human

Description

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Orthologs

SymbolSpecies
sir-2.1 Caenorhabditis elegans
Sir2 Drosophila melanogaster
sirt1 Danio rerio
Sirt1 Mus musculus
Sirt1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2001 SIRT1 activity negatively correlated with age in males Physiological skin Human SIRT1 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1962 Sirt1 activity decreases Molecular bone marrow Mouse Sirt1 —

GO Terms

GO IDGO TermGO Category
GO:0000012 single strand break repair biological_process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000183 chromatin silencing at rDNA biological_process
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair biological_process
GO:0000731 DNA synthesis involved in DNA repair biological_process
GO:0001525 angiogenesis biological_process
GO:0001542 ovulation from ovarian follicle biological_process
GO:0001678 cellular glucose homeostasis biological_process
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0002821 positive regulation of adaptive immune response biological_process
GO:0006260 DNA replication biological_process
GO:0006281 DNA repair biological_process
GO:0006342 chromatin silencing biological_process
GO:0006343 establishment of chromatin silencing biological_process
GO:0006344 maintenance of chromatin silencing biological_process
GO:0006346 methylation-dependent chromatin silencing biological_process
GO:0006364 rRNA processing biological_process
GO:0006471 protein ADP-ribosylation biological_process
GO:0006476 protein deacetylation biological_process
GO:0006642 triglyceride mobilization biological_process
GO:0006974 response to DNA damage stimulus biological_process
GO:0006979 response to oxidative stress biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007283 spermatogenesis biological_process
GO:0007346 regulation of mitotic cell cycle biological_process
GO:0007517 muscle organ development biological_process
GO:0007569 cell aging biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0009267 cellular response to starvation biological_process
GO:0010875 positive regulation of cholesterol efflux biological_process
GO:0010906 regulation of glucose metabolic process biological_process
GO:0016239 positive regulation of macroautophagy biological_process
GO:0016567 protein ubiquitination biological_process
GO:0016575 histone deacetylation biological_process
GO:0018394 peptidyl-lysine acetylation biological_process
GO:0030154 cell differentiation biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway biological_process
GO:0031393 negative regulation of prostaglandin biosynthetic process biological_process
GO:0031648 protein destabilization biological_process
GO:0031937 positive regulation of chromatin silencing biological_process
GO:0032007 negative regulation of TOR signaling cascade biological_process
GO:0032071 regulation of endodeoxyribonuclease activity biological_process
GO:0032088 negative regulation of NF-kappaB transcription factor activity biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0033158 regulation of protein import into nucleus, translocation biological_process
GO:0034391 regulation of smooth muscle cell apoptosis biological_process
GO:0034983 peptidyl-lysine deacetylation biological_process
GO:0035356 cellular triglyceride homeostasis biological_process
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway biological_process
GO:0042127 regulation of cell proliferation biological_process
GO:0042326 negative regulation of phosphorylation biological_process
GO:0042632 cholesterol homeostasis biological_process
GO:0042771 DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043161 proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0045348 positive regulation of MHC class II biosynthetic process biological_process
GO:0045599 negative regulation of fat cell differentiation biological_process
GO:0045739 positive regulation of DNA repair biological_process
GO:0045768 positive regulation of anti-apoptosis biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046628 positive regulation of insulin receptor signaling pathway biological_process
GO:0050872 white fat cell differentiation biological_process
GO:0051097 negative regulation of helicase activity biological_process
GO:0051898 negative regulation of protein kinase B signaling cascade biological_process
GO:0055089 fatty acid homeostasis biological_process
GO:0060766 negative regulation of androgen receptor signaling pathway biological_process
GO:0070301 cellular response to hydrogen peroxide biological_process
GO:0070857 regulation of bile acid biosynthetic process biological_process
GO:0070932 histone H3 deacetylation biological_process
GO:0071356 cellular response to tumor necrosis factor biological_process
GO:0071456 cellular response to hypoxia biological_process
GO:0071479 cellular response to ionizing radiation biological_process
GO:0080134 regulation of response to stress biological_process
GO:2000111 positive regulation of macrophage apoptosis biological_process
GO:2000480 negative regulation of cAMP-dependent protein kinase activity biological_process
GO:2000481 positive regulation of cAMP-dependent protein kinase activity biological_process
GO:2000655 negative regulation of cellular response to testosterone stimulus biological_process
GO:2000757 negative regulation of peptidyl-lysine acetylation biological_process
GO:2000773 negative regulation of cellular senescence biological_process
GO:2000774 positive regulation of cellular senescence biological_process
GO:0000790 nuclear chromatin cellular_component
GO:0005634 nucleus cellular_component
GO:0005635 nuclear envelope cellular_component
GO:0005637 nuclear inner membrane cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005677 chromatin silencing complex cellular_component
GO:0005719 nuclear euchromatin cellular_component
GO:0005720 nuclear heterochromatin cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0016605 PML body cellular_component
GO:0033553 rDNA heterochromatin cellular_component
GO:0035098 ESC/E(Z) complex cellular_component
GO:0002039 p53 binding molecular_function
GO:0003714 transcription corepressor activity molecular_function
GO:0003950 NAD+ ADP-ribosyltransferase activity molecular_function
GO:0004407 histone deacetylase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008022 protein C-terminus binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0017136 NAD-dependent histone deacetylase activity molecular_function
GO:0019213 deacetylase activity molecular_function
GO:0019899 enzyme binding molecular_function
GO:0019904 protein domain specific binding molecular_function
GO:0033558 protein deacetylase activity molecular_function
GO:0034979 NAD-dependent protein deacetylase activity molecular_function
GO:0042393 histone binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0043398 HLH domain binding molecular_function
GO:0043425 bHLH transcription factor binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) molecular_function
GO:0051019 mitogen-activated protein kinase binding molecular_function
GO:0070403 NAD+ binding molecular_function