dickkopf 1 homolog (Xenopus laevis)

Symbol

DKK1 (may also be known as: None)

Organism

Human

Description

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
dkk1b	Danio rerio
Dkk1	Mus musculus
Dkk1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2419	dickkopf homolog 1 precursor increases with age	Molecular	dermis	Human	DKK1	16.2% Increase DNA Methylation
DAA3694	Gene expression of DKK1 decreases with age	Molecular	skin	Human	DKK1	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological_process
GO:0000904	cell morphogenesis involved in differentiation	biological_process
GO:0001706	endoderm formation	biological_process
GO:0001707	mesoderm formation	biological_process
GO:0001942	hair follicle development	biological_process
GO:0002090	regulation of receptor internalization	biological_process
GO:0007165	signal transduction	biological_process
GO:0007275	multicellular organismal development	biological_process
GO:0030326	embryonic limb morphogenesis	biological_process
GO:0030514	negative regulation of BMP signaling pathway	biological_process
GO:0030900	forebrain development	biological_process
GO:0031333	negative regulation of protein complex assembly	biological_process
GO:0032526	response to retinoic acid	biological_process
GO:0033137	negative regulation of peptidyl-serine phosphorylation	biological_process
GO:0048642	negative regulation of skeletal muscle tissue development	biological_process
GO:0060325	face morphogenesis	biological_process
GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway	biological_process
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	biological_process
GO:0090244	Wnt receptor signaling pathway involved in somitogenesis	biological_process
GO:0005576	extracellular region	cellular_component
GO:0005615	extracellular space	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0004871	signal transducer activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0008083	growth factor activity	molecular_function
GO:0048019	receptor antagonist activity	molecular_function
GO:0050750	low-density lipoprotein particle receptor binding	molecular_function
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