SREBF chaperone


SCAP (may also be known as: None)




This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. [provided by RefSeq, Jul 2008]


scp-1 Caenorhabditis elegans
SCAP Drosophila melanogaster
scap Danio rerio
Scap Mus musculus
Scap Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001666 response to hypoxia biological_process
GO:0006994 positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway biological_process
GO:0007568 aging biological_process
GO:0008202 steroid metabolic process biological_process
GO:0008203 cholesterol metabolic process biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0042304 regulation of fatty acid biosynthetic process biological_process
GO:0045540 regulation of cholesterol biosynthetic process biological_process
GO:0045541 negative regulation of cholesterol biosynthetic process biological_process
GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0012507 ER to Golgi transport vesicle membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031410 cytoplasmic vesicle cellular_component
GO:0043234 protein complex cellular_component
GO:0005515 protein binding molecular_function
GO:0051082 unfolded protein binding molecular_function