Fc fragment of IgG, high affinity Ib, receptor (CD64)
Symbol
FCGR1B
(may also be known as: None)
Organism
Human
Description
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2139 | Fc fragment of IgG, high affinity Ib, receptor (CD64) increases with age | Molecular | temporal lobe | Human | FCGR1B | 166.0% Increase Gene Expression Level | |
| DAA2141 | Fc fragment of IgG, high affinity Ib, receptor (CD64) increases with age | Molecular | hippocampus | Human | FCGR1B | 434.2% Increase Gene Expression Level | |
| DAA2143 | Fc fragment of IgG, high affinity Ib, receptor (CD64) increases with age | Molecular | parietal lobe | Human | FCGR1B | 225.5% Increase Gene Expression Level | |
| DAA2145 | Fc fragment of IgG, high affinity Ib, receptor (CD64) increases with age | Molecular | frontal lobe | Human | FCGR1B | 170.4% Increase Gene Expression Level |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | biological_process | |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | biological_process | |
| GO:0006955 | immune response | biological_process | |
| GO:0019221 | cytokine-mediated signaling pathway | biological_process | |
| GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | biological_process | |
| GO:0060333 | interferon-gamma-mediated signaling pathway | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0030669 | clathrin-coated endocytic vesicle membrane | cellular_component | |
| GO:0031901 | early endosome membrane | cellular_component | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0019763 | immunoglobulin receptor activity | molecular_function | |
| GO:0019864 | IgG binding | molecular_function | |