fibulin 1

Symbol

FBLN1 (may also be known as: None)

Organism

Human

Description

Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
fbl-1	Caenorhabditis elegans
CG10323	Drosophila melanogaster
fbln1	Danio rerio
Fbln1	Mus musculus
Fbln1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA3129	Gene expression of FBLN1 decreases with age	Molecular	skin	Human	FBLN1	—

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GO Terms

GO ID	GO Term	GO Category
GO:0007566	embryo implantation	biological_process
GO:0030198	extracellular matrix organization	biological_process
GO:0044419	interspecies interaction between organisms	biological_process
GO:0005576	extracellular region	cellular_component
GO:0005578	proteinaceous extracellular matrix	cellular_component
GO:0005604	basement membrane	cellular_component
GO:0005615	extracellular space	cellular_component
GO:0005625	soluble fraction	cellular_component
GO:0031012	extracellular matrix	cellular_component
GO:0005201	extracellular matrix structural constituent	molecular_function
GO:0005509	calcium ion binding	molecular_function
GO:0016504	peptidase activator activity	molecular_function
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