complement factor D (adipsin)
Symbol
CFD
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| cfd | Danio rerio | |
| Cfd | Mus musculus | |
| Cfd | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2392 | complement factor D preproprotein decreases with age | Molecular | dermis | Human | CFD | 21.7% Decrease DNA Methylation | |
| DAA2441 | complement factor D preproprotein increases with age | Molecular | mesenchymal stem cell | Human | CFD | 22.2% Increase DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0002576 | platelet degranulation | biological_process | |
| GO:0006508 | proteolysis | biological_process | |
| GO:0006956 | complement activation | biological_process | |
| GO:0006957 | complement activation, alternative pathway | biological_process | |
| GO:0007219 | Notch signaling pathway | biological_process | |
| GO:0007596 | blood coagulation | biological_process | |
| GO:0030168 | platelet activation | biological_process | |
| GO:0045087 | innate immune response | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0031093 | platelet alpha granule lumen | cellular_component | |
| GO:0004252 | serine-type endopeptidase activity | molecular_function | |
| GO:0008233 | peptidase activity | molecular_function | |
| GO:0008236 | serine-type peptidase activity | molecular_function | |