poly (ADP-ribose) polymerase 1

Symbol

PARP1

Organism

Human

Description

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
pme-1	Caenorhabditis elegans
Parp	Drosophila melanogaster
parp1	Danio rerio
Parp1	Mus musculus
Parp1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA1999	PARP activity increases with age in males	Molecular	skin	Human	PARP1	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000723	telomere maintenance	biological_process
GO:0006281	DNA repair	biological_process
GO:0006284	base-excision repair	biological_process
GO:0006355	regulation of transcription, DNA-dependent	biological_process
GO:0006366	transcription from RNA polymerase II promoter	biological_process
GO:0006471	protein ADP-ribosylation	biological_process
GO:0016540	protein autoprocessing	biological_process
GO:0032869	cellular response to insulin stimulus	biological_process
GO:0040009	regulation of growth rate	biological_process
GO:0042769	DNA damage response, detection of DNA damage	biological_process
GO:0070212	protein poly-ADP-ribosylation	biological_process
GO:0005622	intracellular	cellular_component
GO:0005634	nucleus	cellular_component
GO:0005635	nuclear envelope	cellular_component
GO:0005654	nucleoplasm	cellular_component
GO:0005667	transcription factor complex	cellular_component
GO:0005730	nucleolus	cellular_component
GO:0003677	DNA binding	molecular_function
GO:0003950	NAD+ ADP-ribosyltransferase activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0008134	transcription factor binding	molecular_function
GO:0008270	zinc ion binding	molecular_function
GO:0016757	transferase activity, transferring glycosyl groups	molecular_function
GO:0046872	metal ion binding	molecular_function
GO:0047485	protein N-terminus binding	molecular_function
GO:0051287	NAD binding	molecular_function
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