ADM (may also be known as: None)




Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]


LOC556502 Danio rerio
Adm Mus musculus
Adm Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001570 vasculogenesis biological_process
GO:0001666 response to hypoxia biological_process
GO:0001843 neural tube closure biological_process
GO:0002026 regulation of the force of heart contraction biological_process
GO:0002031 G-protein coupled receptor internalization biological_process
GO:0006171 cAMP biosynthetic process biological_process
GO:0006701 progesterone biosynthetic process biological_process
GO:0007165 signal transduction biological_process
GO:0007204 elevation of cytosolic calcium ion concentration biological_process
GO:0007267 cell-cell signaling biological_process
GO:0007507 heart development biological_process
GO:0007565 female pregnancy biological_process
GO:0007568 aging biological_process
GO:0008015 blood circulation biological_process
GO:0008209 androgen metabolic process biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0009409 response to cold biological_process
GO:0009611 response to wounding biological_process
GO:0010033 response to organic substance biological_process
GO:0010460 positive regulation of heart rate biological_process
GO:0019933 cAMP-mediated signaling biological_process
GO:0030819 positive regulation of cAMP biosynthetic process biological_process
GO:0031100 organ regeneration biological_process
GO:0031102 neuron projection regeneration biological_process
GO:0031623 receptor internalization biological_process
GO:0032496 response to lipopolysaccharide biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0042475 odontogenesis of dentin-containing tooth biological_process
GO:0042594 response to starvation biological_process
GO:0045768 positive regulation of anti-apoptosis biological_process
GO:0045906 negative regulation of vasoconstriction biological_process
GO:0045909 positive regulation of vasodilation biological_process
GO:0046879 hormone secretion biological_process
GO:0048589 developmental growth biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0055074 calcium ion homeostasis biological_process
GO:0060670 branching involved in embryonic placenta morphogenesis biological_process
GO:0060712 spongiotrophoblast layer development biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005102 receptor binding molecular_function
GO:0005179 hormone activity molecular_function
GO:0005515 protein binding molecular_function
GO:0031700 adrenomedullin receptor binding molecular_function