adrenomedullin

Symbol

ADM (may also be known as: None)

Organism

Human

Description

Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
LOC556502 Danio rerio
Adm Mus musculus
Adm Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2780 Gene expression of ADM increases with age Molecular adipose tissue Human ADM —

GO Terms

GO IDGO TermGO Category
GO:0001570 vasculogenesis biological_process
GO:0001666 response to hypoxia biological_process
GO:0001843 neural tube closure biological_process
GO:0002026 regulation of the force of heart contraction biological_process
GO:0002031 G-protein coupled receptor internalization biological_process
GO:0006171 cAMP biosynthetic process biological_process
GO:0006701 progesterone biosynthetic process biological_process
GO:0007165 signal transduction biological_process
GO:0007204 elevation of cytosolic calcium ion concentration biological_process
GO:0007267 cell-cell signaling biological_process
GO:0007507 heart development biological_process
GO:0007565 female pregnancy biological_process
GO:0007568 aging biological_process
GO:0008015 blood circulation biological_process
GO:0008209 androgen metabolic process biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0009409 response to cold biological_process
GO:0009611 response to wounding biological_process
GO:0010033 response to organic substance biological_process
GO:0010460 positive regulation of heart rate biological_process
GO:0019933 cAMP-mediated signaling biological_process
GO:0030819 positive regulation of cAMP biosynthetic process biological_process
GO:0031100 organ regeneration biological_process
GO:0031102 neuron projection regeneration biological_process
GO:0031623 receptor internalization biological_process
GO:0032496 response to lipopolysaccharide biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0042475 odontogenesis of dentin-containing tooth biological_process
GO:0042594 response to starvation biological_process
GO:0045768 positive regulation of anti-apoptosis biological_process
GO:0045906 negative regulation of vasoconstriction biological_process
GO:0045909 positive regulation of vasodilation biological_process
GO:0046879 hormone secretion biological_process
GO:0048589 developmental growth biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0055074 calcium ion homeostasis biological_process
GO:0060670 branching involved in embryonic placenta morphogenesis biological_process
GO:0060712 spongiotrophoblast layer development biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005102 receptor binding molecular_function
GO:0005179 hormone activity molecular_function
GO:0005515 protein binding molecular_function
GO:0031700 adrenomedullin receptor binding molecular_function