chemokine (C-C motif) receptor 1

Symbol

CCR1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
Ccr1	Mus musculus
Ccr1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data
DAA2405	chemokine (C-C motif) receptor 1 decreases with age	Molecular	dermis	Human	CCR1	16.5% Decrease DNA Methylation
DAA2297	chemokine (C-C motif) receptor 1 increases with age	Molecular	hippocampus	Human	CCR1	93.8% Increase Gene Expression Level
DAA2303	chemokine (C-C motif) receptor 1 increases with age	Molecular	parietal lobe	Human	CCR1	53.9% Increase Gene Expression Level
DAA2454	chemokine (C-C motif) receptor 1 increases with age	Molecular	mesenchymal stem cell	Human	CCR1	31.2% Increase DNA Methylation
DAA2296	Chemokine (C-C motif) receptor 1 increases with age	Molecular	hippocampus	Human	CCR1	182.5% Increase Gene Expression Level
DAA2302	Chemokine (C-C motif) receptor 1 increases with age	Molecular	parietal lobe	Human	CCR1	129.2% Increase Gene Expression Level

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GO Terms

GO ID	GO Term	GO Category
GO:0002407	dendritic cell chemotaxis	biological_process
GO:0006816	calcium ion transport	biological_process
GO:0006874	cellular calcium ion homeostasis	biological_process
GO:0006887	exocytosis	biological_process
GO:0006935	chemotaxis	biological_process
GO:0006954	inflammatory response	biological_process
GO:0006955	immune response	biological_process
GO:0007155	cell adhesion	biological_process
GO:0007166	cell surface receptor linked signaling pathway	biological_process
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	biological_process
GO:0007204	elevation of cytosolic calcium ion concentration	biological_process
GO:0007267	cell-cell signaling	biological_process
GO:0009611	response to wounding	biological_process
GO:0010629	negative regulation of gene expression	biological_process
GO:0019221	cytokine-mediated signaling pathway	biological_process
GO:0030502	negative regulation of bone mineralization	biological_process
GO:0045672	positive regulation of osteoclast differentiation	biological_process
GO:0051928	positive regulation of calcium ion transport	biological_process
GO:0070098	chemokine-mediated signaling pathway	biological_process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological_process
GO:0005886	plasma membrane	cellular_component
GO:0005887	integral to plasma membrane	cellular_component
GO:0009897	external side of plasma membrane	cellular_component
GO:0004435	phosphatidylinositol phospholipase C activity	molecular_function
GO:0004871	signal transducer activity	molecular_function
GO:0004872	receptor activity	molecular_function
GO:0004930	G-protein coupled receptor activity	molecular_function
GO:0004950	chemokine receptor activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0016493	C-C chemokine receptor activity	molecular_function
GO:0019957	C-C chemokine binding	molecular_function
GO:0035717	chemokine (C-C motif) ligand 7 binding	molecular_function
GO:0071791	chemokine (C-C motif) ligand 5 binding	molecular_function
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