clusterin

Symbol

CLU (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]

Orthologs

Symbol	Species
clu	Danio rerio
Clu	Mus musculus
Clu	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data
DAA2168	Clusterin increases with age	Molecular	temporal lobe	Human	CLU	25.9% Increase Gene Expression Level
DAA2178	Clusterin increases with age	Molecular	hippocampus	Human	CLU	33.1% Increase Gene Expression Level
DAA2179	Clusterin increases with age	Molecular	hippocampus	Human	CLU	41.7% Increase Gene Expression Level
DAA2180	Clusterin increases with age	Molecular	hippocampus	Human	CLU	58.9% Increase Gene Expression Level
DAA2191	Clusterin increases with age	Molecular	parietal lobe	Human	CLU	22.5% Increase Gene Expression Level
DAA2192	Clusterin increases with age	Molecular	parietal lobe	Human	CLU	23.5% Increase Gene Expression Level
DAA2193	Clusterin increases with age	Molecular	parietal lobe	Human	CLU	47.9% Increase Gene Expression Level
DAA2202	Clusterin increases with age	Molecular	frontal lobe	Human	CLU	30.9% Increase Gene Expression Level
DAA2203	Clusterin increases with age	Molecular	frontal lobe	Human	CLU	56.5% Increase Gene Expression Level
DAA2201	Clusterin increases with age	Molecular	frontal lobe	Human	CLU	25.5% Increase Gene Expression Level

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GO Terms

GO ID	GO Term	GO Category
GO:0001836	release of cytochrome c from mitochondria	biological_process
GO:0002576	platelet degranulation	biological_process
GO:0006629	lipid metabolic process	biological_process
GO:0006916	anti-apoptosis	biological_process
GO:0006956	complement activation	biological_process
GO:0006958	complement activation, classical pathway	biological_process
GO:0006979	response to oxidative stress	biological_process
GO:0007596	blood coagulation	biological_process
GO:0008219	cell death	biological_process
GO:0008284	positive regulation of cell proliferation	biological_process
GO:0008629	induction of apoptosis by intracellular signals	biological_process
GO:0009611	response to wounding	biological_process
GO:0009615	response to virus	biological_process
GO:0030168	platelet activation	biological_process
GO:0031018	endocrine pancreas development	biological_process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	biological_process
GO:0032463	negative regulation of protein homooligomerization	biological_process
GO:0043065	positive regulation of apoptotic process	biological_process
GO:0043066	negative regulation of apoptotic process	biological_process
GO:0043691	reverse cholesterol transport	biological_process
GO:0045087	innate immune response	biological_process
GO:0045597	positive regulation of cell differentiation	biological_process
GO:0048812	neuron projection morphogenesis	biological_process
GO:0050821	protein stabilization	biological_process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological_process
GO:0051788	response to misfolded protein	biological_process
GO:0061077	chaperone-mediated protein folding	biological_process
GO:0071363	cellular response to growth factor stimulus	biological_process
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	biological_process
GO:0005576	extracellular region	cellular_component
GO:0005615	extracellular space	cellular_component
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005739	mitochondrion	cellular_component
GO:0005783	endoplasmic reticulum	cellular_component
GO:0005792	microsome	cellular_component
GO:0005829	cytosol	cellular_component
GO:0016020	membrane	cellular_component
GO:0016235	aggresome	cellular_component
GO:0030426	growth cone	cellular_component
GO:0031012	extracellular matrix	cellular_component
GO:0031093	platelet alpha granule lumen	cellular_component
GO:0031410	cytoplasmic vesicle	cellular_component
GO:0031966	mitochondrial membrane	cellular_component
GO:0034366	spherical high-density lipoprotein particle	cellular_component
GO:0042583	chromaffin granule	cellular_component
GO:0048471	perinuclear region of cytoplasm	cellular_component
GO:0005515	protein binding	molecular_function
GO:0016887	ATPase activity	molecular_function
GO:0031625	ubiquitin protein ligase binding	molecular_function
GO:0051787	misfolded protein binding	molecular_function
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