DLC1 Rho GTPase activating protein

Symbol

DLC1 (may also be known as: None)

Organism

Human

Description

This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

Orthologs

SymbolSpecies
uncharacterized_E7FB Danio rerio
Dlc1 Mus musculus
Dlc1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2655 Hypermethylation of DLC1 is positively correlated with age Molecular blood Human DLC1 —

GO Terms

GO IDGO TermGO Category
GO:0001843 neural tube closure biological_process
GO:0003007 heart morphogenesis biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006919 activation of caspase activity biological_process
GO:0007165 signal transduction biological_process
GO:0007202 activation of phospholipase C activity biological_process
GO:0007264 small GTPase mediated signal transduction biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008360 regulation of cell shape biological_process
GO:0021575 hindbrain morphogenesis biological_process
GO:0030036 actin cytoskeleton organization biological_process
GO:0030336 negative regulation of cell migration biological_process
GO:0030900 forebrain development biological_process
GO:0032321 positive regulation of Rho GTPase activity biological_process
GO:0032869 cellular response to insulin stimulus biological_process
GO:0032956 regulation of actin cytoskeleton organization biological_process
GO:0035024 negative regulation of Rho protein signal transduction biological_process
GO:0035307 positive regulation of protein dephosphorylation biological_process
GO:0048041 focal adhesion assembly biological_process
GO:0051056 regulation of small GTPase mediated signal transduction biological_process
GO:0051497 negative regulation of stress fiber assembly biological_process
GO:0001725 stress fiber cellular_component
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005884 actin filament cellular_component
GO:0005901 caveola cellular_component
GO:0005925 focal adhesion cellular_component
GO:0045121 membrane raft cellular_component
GO:0005096 GTPase activator activity molecular_function
GO:0005100 Rho GTPase activator activity molecular_function
GO:0005515 protein binding molecular_function
GO:0017166 vinculin binding molecular_function
GO:0030675 Rac GTPase activator activity molecular_function
GO:0042169 SH2 domain binding molecular_function
GO:0043274 phospholipase binding molecular_function