cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Symbol

CDKN2B (may also be known as: None)

Organism

Human

Description

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
LOC100329528 Danio rerio
Cdkn2b Mus musculus
Cdkn2b Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2433 cyclin-dependent kinase inhibitor 2B isoform 2 decreases with age Molecular mesenchymal stem cell Human CDKN2B 16.7% Decrease DNA Methylation
DAA2384 cyclin-dependent kinase inhibitor 2B isoform 2 increases with age Molecular dermis Human CDKN2B 26.0% Increase DNA Methylation

GO Terms

GO IDGO TermGO Category
GO:0000079 regulation of cyclin-dependent protein kinase activity biological_process
GO:0000080 G1 phase of mitotic cell cycle biological_process
GO:0000086 G2/M transition of mitotic cell cycle biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0007050 cell cycle arrest biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0030219 megakaryocyte differentiation biological_process
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway biological_process
GO:0030858 positive regulation of epithelial cell differentiation biological_process
GO:0031575 mitotic cell cycle G1/S transition checkpoint biological_process
GO:0031668 cellular response to extracellular stimulus biological_process
GO:0031670 cellular response to nutrient biological_process
GO:0034097 response to cytokine stimulus biological_process
GO:0042326 negative regulation of phosphorylation biological_process
GO:0050680 negative regulation of epithelial cell proliferation biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0004861 cyclin-dependent protein kinase inhibitor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0016301 kinase activity molecular_function
GO:0019901 protein kinase binding molecular_function