cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Symbol
CDKN1C
(may also be known as: None)
Organism
Human
Description
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Orthologs
Symbol | Species | |
---|---|---|
Cdkn1c | Mus musculus | |
Cdkn1c | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0000079 | regulation of cyclin-dependent protein kinase activity | biological_process | |
GO:0000080 | G1 phase of mitotic cell cycle | biological_process | |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_process | |
GO:0007049 | cell cycle | biological_process | |
GO:0007050 | cell cycle arrest | biological_process | |
GO:0008285 | negative regulation of cell proliferation | biological_process | |
GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | biological_process | |
GO:0033673 | negative regulation of kinase activity | biological_process | |
GO:0042326 | negative regulation of phosphorylation | biological_process | |
GO:0042551 | neuron maturation | biological_process | |
GO:0045892 | negative regulation of transcription, DNA-dependent | biological_process | |
GO:0045893 | positive regulation of transcription, DNA-dependent | biological_process | |
GO:0050680 | negative regulation of epithelial cell proliferation | biological_process | |
GO:0005634 | nucleus | cellular_component | |
GO:0005730 | nucleolus | cellular_component | |
GO:0005737 | cytoplasm | cellular_component | |
GO:0004860 | protein kinase inhibitor activity | molecular_function | |
GO:0004861 | cyclin-dependent protein kinase inhibitor activity | molecular_function | |
GO:0005515 | protein binding | molecular_function | |