adenosine deaminase

Symbol

ADA (may also be known as: None)

Organism

Human

Description

This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
C06G3.5 Caenorhabditis elegans
ada Danio rerio
Ada Mus musculus
Ada Rattus norvegicus
AAH1 Saccharomyces cerevisiae
SPBC1683.02 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2980 Gene expression of ADA decreases with age Molecular skin Human ADA —
DAA2779 Gene expression of ADA decreases with age Molecular adipose tissue Human ADA —

GO Terms

GO IDGO TermGO Category
GO:0001666 response to hypoxia biological_process
GO:0001701 in utero embryonic development biological_process
GO:0001821 histamine secretion biological_process
GO:0001829 trophectodermal cell differentiation biological_process
GO:0001889 liver development biological_process
GO:0001890 placenta development biological_process
GO:0002314 germinal center B cell differentiation biological_process
GO:0002636 positive regulation of germinal center formation biological_process
GO:0002686 negative regulation of leukocyte migration biological_process
GO:0002906 negative regulation of mature B cell apoptosis biological_process
GO:0006144 purine base metabolic process biological_process
GO:0006154 adenosine catabolic process biological_process
GO:0006157 deoxyadenosine catabolic process biological_process
GO:0007155 cell adhesion biological_process
GO:0007568 aging biological_process
GO:0009117 nucleotide metabolic process biological_process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process biological_process
GO:0010460 positive regulation of heart rate biological_process
GO:0030890 positive regulation of B cell proliferation biological_process
GO:0032261 purine nucleotide salvage biological_process
GO:0033089 positive regulation of T cell differentiation in thymus biological_process
GO:0033632 regulation of cell-cell adhesion mediated by integrin biological_process
GO:0042110 T cell activation biological_process
GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep biological_process
GO:0042542 response to hydrogen peroxide biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043101 purine-containing compound salvage biological_process
GO:0043103 hypoxanthine salvage biological_process
GO:0043278 response to morphine biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045187 regulation of circadian sleep/wake cycle, sleep biological_process
GO:0045987 positive regulation of smooth muscle contraction biological_process
GO:0046061 dATP catabolic process biological_process
GO:0046103 inosine biosynthetic process biological_process
GO:0046111 xanthine biosynthetic process biological_process
GO:0046638 positive regulation of alpha-beta T cell differentiation biological_process
GO:0048286 lung alveolus development biological_process
GO:0048541 Peyer's patch development biological_process
GO:0048566 embryonic digestive tract development biological_process
GO:0050728 negative regulation of inflammatory response biological_process
GO:0050850 positive regulation of calcium-mediated signaling biological_process
GO:0050862 positive regulation of T cell receptor signaling pathway biological_process
GO:0055086 nucleobase-containing small molecule metabolic process biological_process
GO:0060169 negative regulation of adenosine receptor signaling pathway biological_process
GO:0060407 negative regulation of penile erection biological_process
GO:0070244 negative regulation of thymocyte apoptosis biological_process
GO:0070256 negative regulation of mucus secretion biological_process
GO:0005615 extracellular space cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005764 lysosome cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016020 membrane cellular_component
GO:0030054 cell junction cellular_component
GO:0031410 cytoplasmic vesicle cellular_component
GO:0032839 dendrite cytoplasm cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0060205 cytoplasmic membrane-bounded vesicle lumen cellular_component
GO:0001883 purine nucleoside binding molecular_function
GO:0004000 adenosine deaminase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0019239 deaminase activity molecular_function
GO:0046872 metal ion binding molecular_function