Changes in fat distribution
PhysiologicalData Availability
Period at which this change occurs is not accurately known
Tissue
References
- Sepe et al. (2011) "Aging and regional differences in fat cell progenitors - a mini-review." Gerontology 57(1):66-75 (PubMed)
- Tchkonia et al. (2010) "Fat tissue, aging, and cellular senescence." Aging Cell 9(5):667-684 (PubMed)
- Kuk et al. (2009) "Age-related changes in total and regional fat distribution." Ageing Res. Rev. 8(4):339-348 (PubMed)
- Delmonico et al. (2009) "Longitudinal study of muscle strength, quality, and adipose tissue infiltration." Am. J. Clin. Nutr. 90(6):1579-1585 (PubMed)
- Cartwright et al. (2007) "Aging in adipocytes: potential impact of inherent, depot-specific mechanisms." Exp. Gerontol. 42(6):463-471 (PubMed)
- Rabkin (2007) "Epicardial fat: properties, function and relationship to obesity." Obes Rev 8(3):253-261 (PubMed)
- Slawik and Vidal-Puig (2006) "Lipotoxicity, overnutrition and energy metabolism in aging." Ageing Res. Rev. 5(2):144-164 (PubMed)
- Raguso et al. (2006) "A 3-year longitudinal study on body composition changes in the elderly: role of physical exercise." Clin Nutr 25(4):573-580 (PubMed)
- Kyle et al. (2001) "Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years." Eur J Clin Nutr 55(8):663-672 (PubMed)
- Matsuzawa et al. (1995) "Pathophysiology and pathogenesis of visceral fat obesity." Obes. Res. 3 Suppl 2:187S-194S (PubMed)
- Kotani et al. (1994) "Sexual dimorphism of age-related changes in whole-body fat distribution in the obese." Int. J. Obes. Relat. Metab. Disord. 18(4):207-202 (PubMed)
- Meunier et al. (1971) "Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies." Clin. Orthop. Relat. Res. 80:147-154 (PubMed)
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Description
With age, there is an increase in abdominal fat, in particular visceral fat, combined with a decrease in lower body subcutaneous fat. These changes can occur independent of changes in total adiposity, body weight or waist circumference. An age-related increase in intermuscular fat in men and women, regardless of changes in weight or subcutaneous fat was also reported. Aging is also generally associated with increases in fat deposition in various tissues, such as the heart, liver, skeletal muscle, and bone marrow.