Pancreatic Beta-cell replication decrease

Physiological

Data Availability

0 to 12 months

Tissue

  • pancreas Changes

References

Referencing provided by LibAge

External Links

Description

Pancreatic Beta-cell replication decreases rapidly in juvenile mice, then declines more slowly in adults. Beta-cells of aged adult mice have extremely low rates of replication, with minimal evidence of turnover. Beta cell replication declines as rodents age. Beta-cells proliferate very slowly in 1-year-old mice, with 1 in 1400 cells replicating per day. The age-dependent decline in Beta-cell replication eventually approaches 0.

Properties

Location
Cellular