Variability in clearance of hepatically metabolized drugs

Physiological

Data Availability

Period at which this change occurs is not accurately known

Tissue

  • liver Changes

References

Referencing provided by LibAge

External Links

Description

Katzung et al. note that 1) the hepatic drug metabolism changes are more pronounced for phase 1 (non-conjugation) vs. phase 2 (conjugation) reactions; 2) the following drugs exhibit age-associated declines in hepatic clearance: alprazolam, barbiturates, carbenoxolone, chlordiazepoxide, clobazam, desmethyldiazepam, diazepam, flurazepam, imipramine, meperidine, nortriptyline, phenylbutazone, propranolol, quinidine/quinine, theophylline, and tolbutamide; and 3) the following drugs do not exhibit age-associated changes in hepatic clearance: ethanol, isoniazid, lidocaine, lorazepam, nitrazepam, oxazepam, prazosin, salicylate, and warfarin.

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