DAA2578 |
Level of miR-15b decreases with age |
Molecular |
T cell |
Human |
MIR15B |
29.4% Decrease miRNA Level |
|
DAA2579 |
Level of miR-206 decreases with age |
Molecular |
T cell |
Human |
MIR206 |
47.4% Decrease miRNA Level |
|
DAA2580 |
Level of miR-18b decreases with age |
Molecular |
T cell |
Human |
MIR18B |
39.3% Decrease miRNA Level |
|
DAA2581 |
Level of miR-101 decreases with age |
Molecular |
T cell |
Human |
MIR101-1 |
49.5% Decrease miRNA Level |
|
DAA2599 |
Telomere shortening |
Physiological |
adipose tissue, skeletal muscle, skin, leukocyte |
Human |
— |
— |
|
DAA934 |
Number of mature B cells leaving the bone marrow declines |
Physiological |
bone marrow, B cell |
Human |
— |
— |
|
DAA935 |
Pro-B cell generation and differentiation declines |
Physiological |
bone marrow, B cell |
Human |
— |
— |
|
DAA939 |
Naive cell number increases and memory cells decrease |
Physiological |
B cell |
Human |
— |
— |
|
DAA940 |
B naive cells' susceptibility to apoptosis decreases |
Physiological |
memory B cell |
Human |
— |
— |
|
DAA944 |
Less antibodies generated |
Physiological |
B cell |
Human |
— |
— |
|
DAA945 |
Thymus involution |
Physiological |
thymus |
Human |
— |
— |
|
DAA948 |
Volume of perivascular space around thymus increases |
Physiological |
thymus |
Human |
— |
— |
|
DAA949 |
Cytomegalovirus infection incidence increases |
Pathological |
immune system |
Human |
— |
— |
|
DAA950 |
Immune response to Epstein-Barr virus decreases in cytomegalovirus positive individuals |
Physiological |
immune system |
Human |
— |
— |
|
DAA952 |
Fewer CD4+ and CD8+ cells |
Physiological |
T cell |
Human |
— |
— |
|
DAA953 |
Increase in cells that are both CD8+ and CD28-null |
Physiological |
T regulatory cell |
Human |
— |
— |
|
DAA954 |
Number of T cell progenitors declines |
Physiological |
T cell progenitor |
Human |
— |
— |
|
DAA955 |
Interleukin-7 production declines |
Physiological |
stromal cell |
Human |
IL7 |
— |
|
DAA956 |
Proliferation is reduced |
Physiological |
lymphocytes |
Human |
— |
— |
|
DAA959 |
telomere shortening |
Molecular |
naïve T cell |
Human |
— |
— |
|
DAA961 |
Increased apoptosis associated with Fas and Fas-ligand expression |
Physiological |
T cell |
Human |
FAS |
— |
|
DAA962 |
Interleukin-2 production in response to influenza vaccine declines |
Physiological |
T cell |
Human |
IL2 |
— |
|
DAA963 |
Expansion into effector cells is reduced |
Physiological |
naïve T cell |
Human |
— |
— |
|
DAA964 |
T-cell diversity declines |
Physiological |
T cell |
Human |
— |
— |
|
DAA965 |
Incidence of anergia increases |
Physiological |
immune system |
Human |
— |
— |
|