DAA919 |
Somatostatin basal levels increase |
Physiological |
plasma |
Human |
SST |
— |
|
DAA910 |
DHEA levels decrease |
Physiological |
plasma |
Human |
— |
— |
|
DAA2027 |
DNA damage acummulates in hematopoietic stem and progenitor cells |
Physiological |
hematopoietic stem cells |
Human |
— |
— |
|
DAA1954 |
Interleukin-15 levels decrease in plasma and muscle |
Physiological |
plasma, muscle |
Mouse |
— |
— |
|
DAA1073 |
Fewer cells and higher apoptosis |
Physiological |
bone marrow |
Human |
— |
— |
|
DAA1959 |
Osteoblast differentiation decreases |
Physiological |
bone marrow |
Mouse |
— |
— |
|
DAA2597 |
Mitochondrial DNA content in non-centenerians decreases with age |
Physiological |
blood |
Human |
— |
— |
|
DAA1991 |
Hematopoietic cells accumulate random mutations |
Physiological |
hematopoietic stem cells |
Human |
— |
— |
|
DAA1215 |
Higher adrenocroticotropic hormone levels |
Physiological |
plasma |
Human |
POMC |
— |
|
DAA1219 |
Morning concentration of oestrone (E1) declines |
Physiological |
plasma |
Human |
— |
— |
|
DAA1221 |
Morning concentration of sex-hormone binding globulin declines |
Physiological |
plasma |
Human |
— |
— |
|
DAA1218 |
Morning concentrations of oestradiol decline |
Physiological |
plasma |
Human |
— |
— |
|
DAA1180 |
Morning concentrations of testosterone decline |
Physiological |
plasma |
Human |
— |
80.0% Decrease Hormone Level |
|
DAA1181 |
Morning IGF1 decline |
Physiological |
plasma |
Human |
IGF1 |
51.0% Decrease Hormone Level |
|
DAA2058 |
Mosaic abnormalities increase |
Physiological |
blood, oral cavity |
Human |
— |
— |
|
DAA1207 |
IL8 level increase |
Physiological |
plasma |
Human |
IL8 |
— |
|
DAA925 |
Increase in follicle stimulating hormone (FSH) and luteinizing hormone (LH) preceding menopause |
Physiological |
plasma |
Human |
— |
— |
|
DAA1200 |
Inhibin levels decline |
Physiological |
plasma |
Human |
— |
Decrease Hormone Level |
|
DAA700 |
Shift in reduced:oxidized glutathione ratio in favour of oxidized gluthione |
Physiological |
blood, lymphocytes |
Mouse |
— |
— |
|
DAA933 |
No changes in erythroid and myeloid progenitor cells evident |
Physiological |
myeloid progenitor cell |
Human |
— |
— |
|
DAA909 |
Mean blood glucose level increases |
Physiological |
plasma |
Human |
— |
— |
|
DAA2013 |
Number and differentiation potential of adipose tissue-derived stem cells declines with age |
Physiological |
mesenchymal stem cell |
Human |
— |
— |
|
DAA2014 |
Microsatellite instability in hematopoietic stem cells and progenitor cells |
Physiological |
hematopoietic stem cells |
Human |
MLH1 |
— |
|
DAA934 |
Number of mature B cells leaving the bone marrow declines |
Physiological |
bone marrow, B cell |
Human |
— |
— |
|
DAA2593 |
Glycosylation of immunoglobulin G molecules changes with age |
Physiological |
blood |
Human |
— |
— |
|