cell division cycle 25C

Symbol

CDC25C (may also be known as: None)

Organism

Human

Description

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
cdc-25.2 Caenorhabditis elegans
Cdc25c Mus musculus
Cdc25c Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3042 Gene expression of CDC25C increases with age Molecular skin Human CDC25C —

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000079 regulation of cyclin-dependent protein kinase activity biological_process
GO:0000086 G2/M transition of mitotic cell cycle biological_process
GO:0000087 M phase of mitotic cell cycle biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0006260 DNA replication biological_process
GO:0007088 regulation of mitosis biological_process
GO:0007089 traversing start control point of mitotic cell cycle biological_process
GO:0008283 cell proliferation biological_process
GO:0035335 peptidyl-tyrosine dephosphorylation biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0051301 cell division biological_process
GO:0051726 regulation of cell cycle biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0004725 protein tyrosine phosphatase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0050699 WW domain binding molecular_function