engulfment and cell motility 1
Symbol
ELMO1
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| elmo1 | Danio rerio | |
| Elmo1 | Mus musculus | |
| Elmo1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006909 | phagocytosis | biological_process | |
| GO:0006911 | phagocytosis, engulfment | biological_process | |
| GO:0006915 | apoptotic process | biological_process | |
| GO:0006928 | cellular component movement | biological_process | |
| GO:0016032 | viral reproduction | biological_process | |
| GO:0016601 | Rac protein signal transduction | biological_process | |
| GO:0030029 | actin filament-based process | biological_process | |
| GO:0030036 | actin cytoskeleton organization | biological_process | |
| GO:0050690 | regulation of defense response to virus by virus | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0005856 | cytoskeleton | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005488 | binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0017124 | SH3 domain binding | molecular_function | |