mediator of DNA-damage checkpoint 1

Symbol

MDC1 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
ptip Drosophila melanogaster
im:7163673 Danio rerio
Mdc1 Mus musculus
Mdc1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3563 Gene expression of MDC1 increases with age Molecular skin Human MDC1 —

GO Terms

GO IDGO TermGO Category
GO:0000724 double-strand break repair via homologous recombination biological_process
GO:0006281 DNA repair biological_process
GO:0006302 double-strand break repair biological_process
GO:0007049 cell cycle biological_process
GO:0031573 intra-S DNA damage checkpoint biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0005925 focal adhesion cellular_component
GO:0005515 protein binding molecular_function
GO:0008022 protein C-terminus binding molecular_function
GO:0070975 FHA domain binding molecular_function