nuclear receptor corepressor 2

Symbol

NCOR2 (may also be known as: None)

Organism

Human

Description

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

Orthologs

Symbol	Species
ncor2	Danio rerio
Ncor2	Mus musculus
Ncor2	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA3559	Gene expression of NCOR2 increases with age	Molecular	skin	Human	NCOR2	—
DAA2742	Hypomethylation of NCOR2 is positively correlated with age	Molecular	blood	Human	NCOR2	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological_process
GO:0001701	in utero embryonic development	biological_process
GO:0003007	heart morphogenesis	biological_process
GO:0006355	regulation of transcription, DNA-dependent	biological_process
GO:0021537	telencephalon development	biological_process
GO:0021846	cell proliferation in forebrain	biological_process
GO:0042593	glucose homeostasis	biological_process
GO:0044255	cellular lipid metabolic process	biological_process
GO:0044281	small molecule metabolic process	biological_process
GO:0045599	negative regulation of fat cell differentiation	biological_process
GO:0050872	white fat cell differentiation	biological_process
GO:0072365	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter	biological_process
GO:0000118	histone deacetylase complex	cellular_component
GO:0005634	nucleus	cellular_component
GO:0005654	nucleoplasm	cellular_component
GO:0005730	nucleolus	cellular_component
GO:0016604	nuclear body	cellular_component
GO:0017053	transcriptional repressor complex	cellular_component
GO:0003677	DNA binding	molecular_function
GO:0003682	chromatin binding	molecular_function
GO:0003714	transcription corepressor activity	molecular_function
GO:0005112	Notch binding	molecular_function
GO:0005515	protein binding	molecular_function
GO:0042826	histone deacetylase binding	molecular_function
GO:0043565	sequence-specific DNA binding	molecular_function
GO:0047485	protein N-terminus binding	molecular_function
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