nuclear receptor corepressor 2

Symbol

NCOR2 (may also be known as: None)

Organism

Human

Description

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

Orthologs

SymbolSpecies
ncor2 Danio rerio
Ncor2 Mus musculus
Ncor2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3559 Gene expression of NCOR2 increases with age Molecular skin Human NCOR2 —
DAA2742 Hypomethylation of NCOR2 is positively correlated with age Molecular blood Human NCOR2 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001701 in utero embryonic development biological_process
GO:0003007 heart morphogenesis biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0021537 telencephalon development biological_process
GO:0021846 cell proliferation in forebrain biological_process
GO:0042593 glucose homeostasis biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045599 negative regulation of fat cell differentiation biological_process
GO:0050872 white fat cell differentiation biological_process
GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000118 histone deacetylase complex cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0016604 nuclear body cellular_component
GO:0017053 transcriptional repressor complex cellular_component
GO:0003677 DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003714 transcription corepressor activity molecular_function
GO:0005112 Notch binding molecular_function
GO:0005515 protein binding molecular_function
GO:0042826 histone deacetylase binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0047485 protein N-terminus binding molecular_function