etoposide induced 2.4
Symbol
EI24
(may also be known as: None)
Organism
Human
Description
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| epg-4 | Caenorhabditis elegans | |
| CG15626-RA | Drosophila melanogaster | |
| ei24 | Danio rerio | |
| Ei24 | Mus musculus | |
| Ei24 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006914 | autophagy | biological_process | |
| GO:0006915 | apoptotic process | biological_process | |
| GO:0006917 | induction of apoptosis | biological_process | |
| GO:0030308 | negative regulation of cell growth | biological_process | |
| GO:0042493 | response to drug | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0031965 | nuclear membrane | cellular_component | |