melanoma antigen family D, 1
Symbol
MAGED1
(may also be known as: None)
Organism
Human
Description
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Maged1 | Mus musculus | |
| Maged1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0006915 | apoptotic process | biological_process | |
| GO:0008624 | induction of apoptosis by extracellular signals | biological_process | |
| GO:0042981 | regulation of apoptotic process | biological_process | |
| GO:0048011 | nerve growth factor receptor signaling pathway | biological_process | |
| GO:0050680 | negative regulation of epithelial cell proliferation | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0043234 | protein complex | cellular_component | |
| GO:0005515 | protein binding | molecular_function | |