phosphatidylinositol glycan anchor biosynthesis, class L
Symbol
PIGL
(may also be known as: None)
Organism
Human
Description
This gene encodes an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CELE_Y52B11C.1 | Caenorhabditis elegans | |
| CG4433 | Drosophila melanogaster | |
| pigl | Danio rerio | |
| Pigl | Mus musculus | |
| Pigl | Rattus norvegicus | |
| GPI12 | Saccharomyces cerevisiae | |
| gpi12 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006501 | C-terminal protein lipidation | biological_process | |
| GO:0006506 | GPI anchor biosynthetic process | biological_process | |
| GO:0016254 | preassembly of GPI anchor in ER membrane | biological_process | |
| GO:0043687 | post-translational protein modification | biological_process | |
| GO:0044267 | cellular protein metabolic process | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0000225 | N-acetylglucosaminylphosphatidylinositol deacetylase activity | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |