CD4 molecule

Symbol

CD4 (may also be known as: None)

Organism

Human

Description

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

Orthologs

Symbol	Species
Cd4	Mus musculus
Cd4	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2654	Hypomethylation of CD4 is positively correlated with age	Molecular	blood	Human	CD4	—

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GO Terms

GO ID	GO Term	GO Category
GO:0001816	cytokine production	biological_process
GO:0006948	induction by virus of host cell-cell fusion	biological_process
GO:0006955	immune response	biological_process
GO:0007155	cell adhesion	biological_process
GO:0007165	signal transduction	biological_process
GO:0007166	cell surface receptor linked signaling pathway	biological_process
GO:0007167	enzyme linked receptor protein signaling pathway	biological_process
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process
GO:0016032	viral reproduction	biological_process
GO:0019059	initiation of viral infection	biological_process
GO:0030217	T cell differentiation	biological_process
GO:0030260	entry into host cell	biological_process
GO:0031295	T cell costimulation	biological_process
GO:0032507	maintenance of protein location in cell	biological_process
GO:0044419	interspecies interaction between organisms	biological_process
GO:0045058	T cell selection	biological_process
GO:0045086	positive regulation of interleukin-2 biosynthetic process	biological_process
GO:0045087	innate immune response	biological_process
GO:0045234	protein palmitoleylation	biological_process
GO:0045860	positive regulation of protein kinase activity	biological_process
GO:0050690	regulation of defense response to virus by virus	biological_process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological_process
GO:0050850	positive regulation of calcium-mediated signaling	biological_process
GO:0050852	T cell receptor signaling pathway	biological_process
GO:0050863	regulation of T cell activation	biological_process
GO:0050870	positive regulation of T cell activation	biological_process
GO:0005769	early endosome	cellular_component
GO:0005788	endoplasmic reticulum lumen	cellular_component
GO:0005789	endoplasmic reticulum membrane	cellular_component
GO:0005886	plasma membrane	cellular_component
GO:0009897	external side of plasma membrane	cellular_component
GO:0016021	integral to membrane	cellular_component
GO:0042101	T cell receptor complex	cellular_component
GO:0045121	membrane raft	cellular_component
GO:0001948	glycoprotein binding	molecular_function
GO:0004872	receptor activity	molecular_function
GO:0004888	transmembrane signaling receptor activity	molecular_function
GO:0005201	extracellular matrix structural constituent	molecular_function
GO:0005515	protein binding	molecular_function
GO:0008270	zinc ion binding	molecular_function
GO:0015026	coreceptor activity	molecular_function
GO:0019899	enzyme binding	molecular_function
GO:0019901	protein kinase binding	molecular_function
GO:0042289	MHC class II protein binding	molecular_function
GO:0042803	protein homodimerization activity	molecular_function
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