activin A receptor, type IB

Symbol

ACVR1B (may also be known as: None)

Organism

Human

Description

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Orthologs

SymbolSpecies
Acvr1b Mus musculus
Acvr1b Rattus norvegicus
acvr1ba Danio rerio
babo Drosophila melanogaster
sma-6 Caenorhabditis elegans
acvr1bb Danio rerio

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2062 activin A receptor, type IB increases with age Molecular ovary Human ACVR1B 51.0% Increase Gene Expression Level
DAA2977 Gene expression of ACVR1B increases with age Molecular skin Human ACVR1B

GO Terms

GO IDGO TermGO Category
GO:0000082 G1/S transition of mitotic cell cycle biological_process
GO:0001701 in utero embryonic development biological_process
GO:0001942 hair follicle development biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006917 induction of apoptosis biological_process
GO:0007165 signal transduction biological_process
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway biological_process
GO:0007417 central nervous system development biological_process
GO:0009790 embryo development biological_process
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation biological_process
GO:0018107 peptidyl-threonine phosphorylation biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0032924 activin receptor signaling pathway biological_process
GO:0032927 positive regulation of activin receptor signaling pathway biological_process
GO:0045648 positive regulation of erythrocyte differentiation biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046545 development of primary female sexual characteristics biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016020 membrane cellular_component
GO:0048179 activin receptor complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004675 transmembrane receptor protein serine/threonine kinase activity molecular_function
GO:0004702 receptor signaling protein serine/threonine kinase activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0005024 transforming growth factor beta-activated receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016361 activin receptor activity, type I molecular_function
GO:0017002 activin-activated receptor activity molecular_function
GO:0019838 growth factor binding molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function
GO:0034711 inhibin binding molecular_function
GO:0046332 SMAD binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0048185 activin binding molecular_function