mitogen-activated protein kinase kinase kinase 6
Symbol
MAP3K6
(may also be known as: None)
Organism
Human
Description
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| nsy-1 | Caenorhabditis elegans | |
| Map3k6 | Mus musculus | |
| Map3k6 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000165 | MAPKKK cascade | biological_process | |
| GO:0000186 | activation of MAPKK activity | biological_process | |
| GO:0006468 | protein phosphorylation | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0007257 | activation of JUN kinase activity | biological_process | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0000287 | magnesium ion binding | molecular_function | |
| GO:0004674 | protein serine/threonine kinase activity | molecular_function | |
| GO:0004709 | MAP kinase kinase kinase activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |