TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa

Symbol

TAF1C (may also be known as: None)

Organism

Human

Description

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]

Orthologs

SymbolSpecies
si:ch1073-170h8.3 Danio rerio
Taf1c Mus musculus
Taf1c Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3523 Gene expression of TAF1C increases with age Molecular skin Human TAF1C —

GO Terms

GO IDGO TermGO Category
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006360 transcription from RNA polymerase I promoter biological_process
GO:0006361 transcription initiation from RNA polymerase I promoter biological_process
GO:0006362 transcription elongation from RNA polymerase I promoter biological_process
GO:0006363 termination of RNA polymerase I transcription biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0010467 gene expression biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0003677 DNA binding molecular_function