O-linked N-acetylglucosamine (GlcNAc) transferase

Symbol

OGT (may also be known as: None)

Organism

Human

Description

This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Orthologs

SymbolSpecies
ogt-1 Caenorhabditis elegans
sxc Drosophila melanogaster
ogt.2 Danio rerio
Ogt Mus musculus
Ogt Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3491 Gene expression of OGT increases with age Molecular skin Human OGT —

GO Terms

GO IDGO TermGO Category
GO:0006493 protein O-linked glycosylation biological_process
GO:0006915 apoptotic process biological_process
GO:0006917 induction of apoptosis biological_process
GO:0007165 signal transduction biological_process
GO:0007584 response to nutrient biological_process
GO:0030854 positive regulation of granulocyte differentiation biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0035020 regulation of Rac protein signal transduction biological_process
GO:0043085 positive regulation of catalytic activity biological_process
GO:0043981 histone H4-K5 acetylation biological_process
GO:0043982 histone H4-K8 acetylation biological_process
GO:0043984 histone H4-K16 acetylation biological_process
GO:0045862 positive regulation of proteolysis biological_process
GO:0046626 regulation of insulin receptor signaling pathway biological_process
GO:0048015 phosphatidylinositol-mediated signaling biological_process
GO:0051571 positive regulation of histone H3-K4 methylation biological_process
GO:0070207 protein homotrimerization biological_process
GO:0071300 cellular response to retinoic acid biological_process
GO:0000123 histone acetyltransferase complex cellular_component
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005813 centrosome cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0070688 MLL5-L complex cellular_component
GO:0005515 protein binding molecular_function
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding molecular_function
GO:0008047 enzyme activator activity molecular_function
GO:0008289 lipid binding molecular_function
GO:0008375 acetylglucosaminyltransferase activity molecular_function
GO:0016262 protein N-acetylglucosaminyltransferase activity molecular_function
GO:0016757 transferase activity, transferring glycosyl groups molecular_function
GO:0042277 peptide binding molecular_function
GO:0043995 histone acetyltransferase activity (H4-K5 specific) molecular_function
GO:0043996 histone acetyltransferase activity (H4-K8 specific) molecular_function
GO:0046972 histone acetyltransferase activity (H4-K16 specific) molecular_function
GO:0048029 monosaccharide binding molecular_function