GTP binding protein 3 (mitochondrial)

Symbol

GTPBP3 (may also be known as: None)

Organism

Human

Description

This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2010]

Orthologs

SymbolSpecies
CELE_F39B2.7 Caenorhabditis elegans
CG18528 Drosophila melanogaster
gtpbp3 Danio rerio
Gtpbp3 Mus musculus
Gtpbp3 Rattus norvegicus
MSS1 Saccharomyces cerevisiae
mss1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4203 Gene expression of GTPBP3 increases with age Molecular skin Human GTPBP3 —

GO Terms

GO IDGO TermGO Category
GO:0006400 tRNA modification biological_process
GO:0005622 intracellular cellular_component
GO:0005739 mitochondrion cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003924 GTPase activity molecular_function
GO:0005525 GTP binding molecular_function