SET domain, bifurcated 2

Symbol

SETDB2 (may also be known as: None)

Organism

Human

Description

Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM, Mar 2008]

Orthologs

SymbolSpecies
Setdb2 Mus musculus
Setdb2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4180 Gene expression of SETDB2 increases with age Molecular skin Human SETDB2 —

GO Terms

GO IDGO TermGO Category
GO:0001947 heart looping biological_process
GO:0007049 cell cycle biological_process
GO:0007059 chromosome segregation biological_process
GO:0007067 mitosis biological_process
GO:0007275 multicellular organismal development biological_process
GO:0016568 chromatin modification biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0051301 cell division biological_process
GO:0051567 histone H3-K9 methylation biological_process
GO:0070986 left/right axis specification biological_process
GO:0005634 nucleus cellular_component
GO:0005694 chromosome cellular_component
GO:0003677 DNA binding molecular_function
GO:0008168 methyltransferase activity molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0016740 transferase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0046974 histone methyltransferase activity (H3-K9 specific) molecular_function