APH1B gamma secretase subunit
Symbol
APH1B
(may also be known as: None)
Organism
Human
Description
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| aph-1 | Drosophila melanogaster | |
| Aph1c | Mus musculus | |
| Aph1b | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006915 | apoptotic process | biological_process | |
| GO:0007219 | Notch signaling pathway | biological_process | |
| GO:0007220 | Notch receptor processing | biological_process | |
| GO:0008624 | induction of apoptosis by extracellular signals | biological_process | |
| GO:0016485 | protein processing | biological_process | |
| GO:0031293 | membrane protein intracellular domain proteolysis | biological_process | |
| GO:0043085 | positive regulation of catalytic activity | biological_process | |
| GO:0048011 | nerve growth factor receptor signaling pathway | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0030133 | transport vesicle | cellular_component | |
| GO:0004175 | endopeptidase activity | molecular_function | |
| GO:0004190 | aspartic-type endopeptidase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008233 | peptidase activity | molecular_function | |