tripartite motif containing 8
Symbol
TRIM8
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| trim8b | Danio rerio | |
| Trim8 | Mus musculus | |
| Trim8 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2933 | Gene expression of TRIM8 increases with age | Molecular | adipose tissue | Human | TRIM8 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0008150 | biological_process | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0016605 | PML body | cellular_component | |
| GO:0043231 | intracellular membrane-bounded organelle | cellular_component | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0016874 | ligase activity | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |