thioredoxin domain containing 5 (endoplasmic reticulum)
Symbol
TXNDC5
(may also be known as: None)
Organism
Human
Description
This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| prtp | Drosophila melanogaster | |
| txndc5 | Danio rerio | |
| Txndc5 | Mus musculus | |
| Txndc5 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006662 | glycerol ether metabolic process | biological_process | |
| GO:0006892 | post-Golgi vesicle-mediated transport | biological_process | |
| GO:0006916 | anti-apoptosis | biological_process | |
| GO:0016044 | cellular membrane organization | biological_process | |
| GO:0045454 | cell redox homeostasis | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005788 | endoplasmic reticulum lumen | cellular_component | |
| GO:0043202 | lysosomal lumen | cellular_component | |
| GO:0009055 | electron carrier activity | molecular_function | |
| GO:0015035 | protein disulfide oxidoreductase activity | molecular_function | |
| GO:0016853 | isomerase activity | molecular_function | |