dual specificity phosphatase 16
Symbol
DUSP16
(may also be known as: None)
Organism
Human
Description
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| vhp-1 | Caenorhabditis elegans | |
| puc | Drosophila melanogaster | |
| dusp16 | Danio rerio | |
| Dusp16 | Mus musculus | |
| Dusp16 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | biological_process | |
| GO:0006470 | protein dephosphorylation | biological_process | |
| GO:0016311 | dephosphorylation | biological_process | |
| GO:0045204 | MAPK export from nucleus | biological_process | |
| GO:0045209 | MAPK phosphatase export from nucleus, leptomycin B sensitive | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0016023 | cytoplasmic membrane-bounded vesicle | cellular_component | |
| GO:0004721 | phosphoprotein phosphatase activity | molecular_function | |
| GO:0004725 | protein tyrosine phosphatase activity | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0016791 | phosphatase activity | molecular_function | |
| GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity | molecular_function | |