wingless-type MMTV integration site family, member 10A

Symbol

WNT10A (may also be known as: None)

Organism

Human

Description

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
wnt10a Danio rerio
Wnt10a Mus musculus
Wnt10a Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4156 Gene expression of WNT10A increases with age Molecular skin Human WNT10A —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1283 wingless related MMTV integration site 10a Molecular cochlea Mouse Wnt10a 16.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0001942 hair follicle development biological_process
GO:0007275 multicellular organismal development biological_process
GO:0008585 female gonad development biological_process
GO:0009798 axis specification biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0014033 neural crest cell differentiation biological_process
GO:0031069 hair follicle morphogenesis biological_process
GO:0042476 odontogenesis biological_process
GO:0042487 regulation of odontogenesis of dentin-containing tooth biological_process
GO:0043586 tongue development biological_process
GO:0043588 skin development biological_process
GO:0048730 epidermis morphogenesis biological_process
GO:0048733 sebaceous gland development biological_process
GO:0060070 canonical Wnt receptor signaling pathway biological_process
GO:0071560 cellular response to transforming growth factor beta stimulus biological_process
GO:0005576 extracellular region cellular_component
GO:0005578 proteinaceous extracellular matrix cellular_component
GO:0005615 extracellular space cellular_component
GO:0005886 plasma membrane cellular_component
GO:0001664 G-protein coupled receptor binding molecular_function