F-box protein 11

Symbol

FBXO11 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

Orthologs

SymbolSpecies
dre-1 Caenorhabditis elegans
FBX011 Drosophila melanogaster
uncharacterized_F1Q8 Danio rerio
Fbxo11 Mus musculus
Fbxo11 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006464 protein modification process biological_process
GO:0006511 ubiquitin-dependent protein catabolic process biological_process
GO:0007605 sensory perception of sound biological_process
GO:0016567 protein ubiquitination biological_process
GO:0035246 peptidyl-arginine N-methylation biological_process
GO:0000151 ubiquitin ligase complex cellular_component
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0004842 ubiquitin-protein ligase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0016274 protein-arginine N-methyltransferase activity molecular_function
GO:0046872 metal ion binding molecular_function