caldesmon 1

Symbol

CALD1 (may also be known as: None)

Organism

Human

Description

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
cald1 Danio rerio
Cald1 Mus musculus
Cald1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3025 Gene expression of CALD1 increases with age Molecular skin Human CALD1 —

GO Terms

GO IDGO TermGO Category
GO:0006928 cellular component movement biological_process
GO:0006936 muscle contraction biological_process
GO:0032092 positive regulation of protein binding biological_process
GO:0051017 actin filament bundle assembly biological_process
GO:0005624 membrane fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005884 actin filament cellular_component
GO:0005886 plasma membrane cellular_component
GO:0014069 postsynaptic density cellular_component
GO:0015629 actin cytoskeleton cellular_component
GO:0030016 myofibril cellular_component
GO:0030478 actin cap cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0043197 dendritic spine cellular_component
GO:0003779 actin binding molecular_function
GO:0005516 calmodulin binding molecular_function
GO:0005523 tropomyosin binding molecular_function
GO:0017022 myosin binding molecular_function