DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
Symbol
Organism
Description
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| hel-1 | Caenorhabditis elegans | |
| ddx39b | Danio rerio | |
| Ddx39b | Mus musculus | |
| Ddx39b | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000245 | spliceosome assembly | biological_process | |
| GO:0000398 | nuclear mRNA splicing, via spliceosome | biological_process | |
| GO:0006406 | mRNA export from nucleus | biological_process | |
| GO:0006810 | transport | biological_process | |
| GO:0008380 | RNA splicing | biological_process | |
| GO:0010501 | RNA secondary structure unwinding | biological_process | |
| GO:0046784 | intronless viral mRNA export from host nucleus | biological_process | |
| GO:0000346 | transcription export complex | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005681 | spliceosomal complex | cellular_component | |
| GO:0005687 | U4 snRNP | cellular_component | |
| GO:0005688 | U6 snRNP | cellular_component | |
| GO:0016607 | nuclear speck | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003676 | nucleic acid binding | molecular_function | |
| GO:0003723 | RNA binding | molecular_function | |
| GO:0004004 | ATP-dependent RNA helicase activity | molecular_function | |
| GO:0004386 | helicase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0008026 | ATP-dependent helicase activity | molecular_function | |
| GO:0008186 | RNA-dependent ATPase activity | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0017070 | U6 snRNA binding | molecular_function | |
| GO:0030621 | U4 snRNA binding | molecular_function | |
| GO:0043008 | ATP-dependent protein binding | molecular_function | |