fat mass and obesity associated

Symbol

FTO (may also be known as: None)

Organism

Human

Description

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

Orthologs

SymbolSpecies
fto Danio rerio
Fto Mus musculus
Fto Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4107 Gene expression of FTO decreases with age Molecular skin Human FTO —

GO Terms

GO IDGO TermGO Category
GO:0001659 temperature homeostasis biological_process
GO:0006307 DNA dealkylation involved in DNA repair biological_process
GO:0010883 regulation of lipid storage biological_process
GO:0035552 oxidative single-stranded DNA demethylation biological_process
GO:0035553 oxidative single-stranded RNA demethylation biological_process
GO:0040014 regulation of multicellular organism growth biological_process
GO:0042245 RNA repair biological_process
GO:0044065 regulation of respiratory system process biological_process
GO:0060612 adipose tissue development biological_process
GO:0070350 regulation of white fat cell proliferation biological_process
GO:0070989 oxidative demethylation biological_process
GO:0080111 DNA demethylation biological_process
GO:0005634 nucleus cellular_component
GO:0008198 ferrous iron binding molecular_function
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen molecular_function
GO:0035515 oxidative RNA demethylase activity molecular_function
GO:0035516 oxidative DNA demethylase activity molecular_function
GO:0043734 DNA-N1-methyladenine dioxygenase activity molecular_function
GO:0046872 metal ion binding molecular_function